This keynote address offers an overview of Asia in an increasingly fragile world. Climate change is making the monsoon more erratic, bringing more drought and more flood, signaled by the devastating flood of Pakistan in August 2022. Extreme weather and rising sea levels are increasing the “human flow” of migrants, especially into Asia's megacities. Climate change reacts with other trends: the increased inequalities willed by a generation of neoliberal policies, the authoritarian turn in politics, and the return of geopolitical tensions resulting from China's spectacular rise. More dialogue between the sciences and the social sciences is needed to address these multiple fragilities.